Tau cas: 224785-91-5 Tātai rāpoi:C23H33ClN6O4S
| Te Whakarewa | 214-216°C |
| Kiato | N/A |
| pāmahana rokiroki | Ko te hau hau, 2-8°C |
| whakarewatanga | N/A |
| mahi whatu | N/A |
| Te ahua | White ki Off-White Cyrstalline |
| Maamaa | ≥98% |
Ko ia te kaihoko tuarua ki te hokohoko me te whai painga ki te kore i whakaitihia te wa o te timatanga ma te inu i te rongoa i runga i te kopu.Ko te 30 nga wa e kaha ake ana hei aukati i te PDE5 (te tikanga IC50, 3.9 nM) atu i te sildenafil me te 10 te kaha ake i te tadalafil, me te whiriwhiringa nui ake (> nga wa 1,000) mo te PDE5 tangata mo te PDE2, PDE3, me te PDE4 me te tangata. ngawari te whiriwhiri (>80 wa) mo te PDE1.Ko te whiriwhiringa aukati PDE me te kaha in vitro me in vivo o te aukati PDE5 hou.i tino whakakorehia te hydrolysis o cGMP na PDE5, me te IC50 o 0.7 nM (sildenafil 6.6 nM).Ko te IC50 o mo PDE1 ko 180 nM, mo PDE6 11 nM, a mo PDE2, PDE3 me PDE4 neke atu i te 1,000 nM.
He momo aukati phsphodiesterase momo 5 (PDE5).
Tohutohu a te taote mo te whakamahi
