Te nama cas: 144701-48-4 Tātai rāpoi:C33H30N4O2 Atahanga Whakaatu

Tau cas: 144701-48-4 Tātai rāpoi:C33H30N4O2

Whakaahuatanga Poto:

Te nama cas: 144701-48-4
Ingoa matū:
Tātai rāpoi:C33H30N4O2

Synonyms：MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277; PRITOR; BIBR 277; misartan; BIBR 277SE

Tukuna he imeera ki a matou

Taipitopito Hua

Tohu Hua

Whakatakotoranga Hua

Te Whakarewa	261-263°C
Kiato	1.16 (whakatau tata)
pāmahana rokiroki	Te hau hau, Te Pamahana rūma 2-8°C
whakarewatanga	DMSO: >5 mg/mL i te 60 °C
mahi whatu	N/A
Te ahua	Mārō-Ma
Maamaa	≥98%

Whakaahuatanga

i whakarewahia i te US mo te maimoatanga o te whakaheke toto.Ka taea te whakarite i roto i nga hikoinga e waru timata mai i te methyl 4-amino-3-methyl benzoate;ka puta te huringa tuatahi me te tuarua ki roto i te mowhiti benzimidazole i nga kaupae 4 me te 6.ka aukati i te mahi a te angiotensin II (Ang II), te ngota ngota whai hua tuatahi o te punaha renin-angiotensin-aldosterone (RAAS).Koia te tuaono o tenei karaehe o 《sartans》 ka hokona i muri i te roopu matua Losartan.Ko tana paanga roa (24h-hawhe-ora) te rereketanga nui me etahi atu antagonists angiotensin II.Kaore i rite ki etahi atu raau taero i roto i tenei waahanga, kaore e whakawhirinaki ana tana mahi ki te huri hei metabolite kaha, ko te 1-O-acylglucuronide te metabolite matua e kitea ana i roto i te tangata. angiotensin II i te mea kaore he hononga mo nga momo iti o te AT2, etahi atu kaiwhiwhi ranei e uru ana ki te ture cardiovascular.I roto i te maha o nga rangahau haumanu, i te wa kotahi inenga o ia ra, i puta nga hua whakaheke toto-toto me te iti o nga paanga o te taha (ina koa te mare e pa ana ki te maimoatanga e pa ana ki te aukati ACE i nga turoro pakeke).